Independent list · re-checked September 28, 2026 · published by Primortul LLC

PR firms in California

2 of the 14 PR firms on this list are based in California (CA), in San Francisco. The other 12 are based elsewhere on the list. Who leads them, the work they can show, and why each one made the list. This is the list, not a ranking of the state. Nobody pays to be ranked.

  1. 06 on the list · San Francisco, CA

    Real Chemistry

    500+ people

    Real Chemistry is a healthcare-only communications and marketing group founded by chairman Jim Weiss and backed by New Mountain Capital, with 14 office hubs including Boston, Chicago, New York, San Francisco, Washington, D.C., London and Zurich. It provides integrated and medical communications, market access, precision media, analytics and commercial services to pharmaceutical and biotech companies, saying it works with the top 20 pharma companies. O'Dwyer's ranks it second among independent PR firms with $560 million in 2025 net fees and 2,034 staff.

    Why it’s hereThe second-largest independent PR firm in O'Dwyer's 2025 rankings and MM+M's 2025 Healthcare Network of the Year.

    Who leads itShankar Narayanan, Chief Executive Officer.

    Estimated cost

    Estimated: $8,000–$15,000/mo, typical for US PR retainers; not a quote.

    Typical industry estimate, not a quote from any firm on this list.

    healthcare communications · medical communications · market access · precision media · analytics

  2. 14 on the list · San Francisco, CA

    Hotwire

    201–500 people

    Hotwire is a technology communications and marketing agency owned by Australia's Enero Group, with US operations alongside offices in the UK, Germany, France, Spain, Italy, Australia and across Asia. Its services span public relations, digital and account-based marketing, research, channel marketing, measurement, content and AI consulting, and its client logos include Adobe, Akamai, eBay, Meta, Salesforce and SAP. O'Dwyer's ranks it 16th among independents with $53 million in 2025 net fees and 258 staff.

    Why it’s hereA technology-specialist network ranked 16th on O'Dwyer's independent list, with named enterprise software and platform clients.

    Who leads itGrant Toups, Global CEO.

    Work they can showMultiverse. PR program to make the company a headline name in quantum AI. Finwave. Media relations that built the company's authority in Spanish fintech press.

    Estimated cost

    Estimated: $8,000–$15,000/mo, typical for US PR retainers; not a quote.

    Typical industry estimate, not a quote from any firm on this list.

    technology PR · B2B marketing · account-based marketing · analyst relations · AI consulting

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